simultaneous spectrophotometric determination of amlodipine and metoprolol by principal componentregression multivariate calibration and comparison with hplc

multi-drug therapy in high blood pressure is appreciated to achieve a normalblood pressure.a simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (amd) and metoprolol(met) in pharmacutical preparations. calibration matrix contains 3.402 µgml -1 to 170.130 µgml -1 and from 13.060 µgml -1 to 65.3 µgml -1 amlodipine and metoprolol, respectively. the proposedmethod was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneousdetermination of amlodipine (amd) and metoprololin different pharmaceutical preparations.